COVID-19 Scan for Oct 29, 2021

Sufferers with current most cancers remedy at increased threat of poor COVID outcomes

Most cancers sufferers who acquired systemic therapy like chemotherapy or radiation within the 3 months earlier than testing constructive for COVID-19 have been at elevated threat of demise, admission to an intensive care unit (ICU), and hospitalization, in response to a examine yesterday in JAMA Oncology.

Researchers from the College of Texas MD Anderson Most cancers Middle analyzed the scientific outcomes within the digital well being information of 507,307 US adults with and with no analysis of most cancers who examined constructive for COVID-19 from Jan 1 to Dec 31, 2020.

Among the many sufferers, 14,287 (2.8%) had most cancers, whereas 493,020 (97.2%) didn’t. Of the most cancers sufferers, 4,296 (30.1%) had acquired current therapy and 9,991 (69%) had not. Common affected person age was 48.4 years, and 55.4% have been girls. Most cancers sufferers have been considerably older than non-cancer sufferers (median age, 67 vs 48 years) and had increased Charlson-Deyo Comorbidity Index scores, an indicator of poorer survival.

No matter therapy standing, most cancers sufferers have been extra seemingly than non-cancer sufferers to die (7.8% of most cancers sufferers with current therapy, 5.0% of most cancers sufferers with out current therapy, and 1.6% of non-cancer sufferers).

In an adjusted evaluation, in contrast with non-cancer sufferers, most cancers sufferers with out current therapy had comparable or superior outcomes (odds ratio [OR] for demise, 0.93; OR for mechanical air flow, 0.61).

However most cancers sufferers who acquired current therapy have been at increased threat for demise (OR, 1.74) and hospitalization (OR, 1.19). And, relative to sufferers with nonmetastatic stable tumors, sufferers with metastatic tumors or hematologic (blood) cancers had an OR for demise of two.36 and an OR for mechanical air flow of 0.87.

Charges of COVID-19 demise, mechanical air flow, ICU keep, and hospitalization all fell throughout 2020. Within the first quarter of the yr, sufferers with current most cancers therapy had a demise fee of 11.5%, which fell to eight.4% within the final quarter.
Oct 28 JAMA Oncol examine


GAO proposes 16 new suggestions on COVID-19 reduction efforts

In its eighth report of COVID-19 reduction below the CARES Act, the US Authorities Accountability Workplace (GAO) this week made 16 new suggestions to strengthen the federal government’s pandemic response within the areas of healthcare employee reduction, restoration funds, unemployment insurance coverage fraud, and employee security.

“The federal government should stay vigilant and agile to handle the evolving COVID-19 pandemic and its cascading impacts,” the GAO mentioned within the report. “Moreover, because the administration implements the provisions within the COVID-19 reduction legal guidelines, the scale and scope of those efforts—from distributing funding to implementing new packages—demand sturdy accountability and oversight.”

Since June 2020, the GAO has made 209 suggestions in its COVID-19 reviews, and, as of Sep 30, businesses have addressed 33 of them and partially addressed one other 48.

For instance of 1 of the 16 new suggestions, the GAO recommends that the Occupational Security and Well being Administration (OSHA) assess varied challenges associated to sources, communication, and steering that the company has confronted in its response to COVID-19 and take actions as warranted.

“The progress in vaccinating the nation is heartening, however GAO’s overview makes clear how a lot stays to be accomplished to assist the nation totally rebound from the pandemic,” mentioned Gene L. Dodaro, US comptroller basic and head of the GAO, in a GAO information launch. “If swiftly and successfully carried out, GAO’s new and former recommendations may also help help the restoration and put us in a stronger place to take care of future well being emergencies.”
Oct 27 GAO report
Oct 27 GAO information launch

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