Information Scan for Nov 10, 2021

Dexamethasone tied to decrease threat of dying, extreme COVID-19

The corticosteroid dexamethasone was related to a 56% decrease threat of dying and intensive care unit (ICU) admission amongst hospitalized COVID-19 sufferers and is protected to make use of in monitored diabetes sufferers, based on analysis introduced at this week’s Society for Endocrinology annual convention in Edinburgh, Scotland.

The unpublished observational examine concerned information from 1,372 COVID-19 sufferers admitted to Imperial Faculty NHS Belief hospitals through the second pandemic wave (Nov 1, 2020, to Jan 31, 2021), when dexamethasone was routinely utilized in COVID-19 sufferers, and 889 sufferers admitted through the first wave (Mar 9 to Apr 22, 2020), earlier than the anti-inflammatory drug was utilized in these sufferers.

Dexamethasone was tied to a 56% decrease threat of dying by 30 days and a 56% decrease fee of ICU admission. And whereas sufferers with diabetes who take dexamethasone are at increased threat of excessive blood glucose (odds ratio, 22.5) and poor COVID-19 outcomes, the chance of dying or ICU admission within the examine was not increased in sufferers with these issues. These sufferers did, nevertheless, require the usage of further medicines to regulate blood glucose and forestall severe diabetes issues.

The dying fee was considerably decrease in second-wave than in first-wave sufferers (18.8% vs 27.6%), for a 31.8% lowered threat. Threat components for dying included male intercourse, hypertension, frailty, and impaired kidney operate.

Charges of ICU admission weren’t totally different between the 2 pandemic waves, which the authors stated may very well be attributed to the emergence and dominance of SARS-CoV-2 variants throughout that point.

The researchers famous that dexamethasone has been used routinely in sufferers needing supplementary oxygen and mechanical air flow because it was proven to enhance their outcomes within the RECOVERY trial in 2020.

Senior writer Victoria Salem, MB BS, PhD, stated in a Society for Endocrinology information launch that the workforce had been nervous that dexamethasone may very well be a “double-edged sword” for diabetes sufferers.

“And whereas we did see a rise in steroid-induced diabetes and worsened diabetes, deaths have been considerably lowered in wave two for all sufferers,” she stated. “We now really feel assured utilizing dexamethasone for sufferers with diabetes sooner or later, simply with the caveat that it might lead to a short-term worsening of their situation.”
Nov 9 Society for Endocrinology summary and information launch


Earlier SARS expertise doesn’t assuage healthcare COVID-19 stress

A examine in the present day in PLOS One reveals that healthcare employees’ (HCWs’) earlier expertise with the 2003 SARS outbreak neither prevented them from experiencing emotional misery nor elevated their misery through the COVID-19 pandemick.

The examine was based mostly on a web based survey from Might to July 2020 of three,852 HCWs within the higher Toronto space, together with 1,256 nurses, 345 physicians, 1,034 allied well being workers, and 1,243 non-clinical workers. Virtually 30% had labored in healthcare through the 2003 SARS (extreme acute respiratory syndrome) outbreak in Canada.

Half of respondents (50.2%) exhibited indicators of post-traumatic stress dysfunction (PTSD), and 31.5% had signs of melancholy. Those that labored through the SARS outbreak skilled decrease scores of PTSD (P = 0.002) and melancholy (P < 0.001), however these variations weren’t considerably vital after adjusting for age and profession expertise.

Non-clinical workers have been extra more likely to undergo PTSD, melancholy, and nervousness, a pattern additionally seen in research based mostly on employees in Singapore and the USA.

“Non-clinical workers might expertise much less management over their work conditions and decrease self-efficacy because it pertains to core medical information and obtain much less devoted schooling referring to the pandemic in comparison with medical HCWs which can account for this noticed distinction,” the authors wrote.

In an accompanying writer interview, first writer Rima Styra, MD, MEd, of College Well being Community, Toronto, stated survey respondents additionally reported new or rising use of alcohol and sedatives, and new sleep disturbances.

“Sleep disturbances might sign that wellbeing is impacted,” she stated.
Nov 10 PLOS One


Wisconsin probes CWD detection at one other deer farm

Agriculture officers in Wisconsin yesterday reported {that a} white-tail deer at a deer farm in Eau Claire County has examined optimistic for power losing illness (CWD).

In a press release the Wisconsin Division of Agriculture, Commerce, and Client Safety (DATCP) stated the 3-year-old buck that examined optimistic was a part of an approximate 15-deer herd on the searching ranch. Eau Claire County is in west central Wisconsin.

The opposite animals are underneath quarantine through the state and federal investigation. The farm obtained the animal from a deer farm in Waukesha County, which has additionally been positioned in quarantine.

Earlier this yr, CWD was detected at deer farms in different Wisconsin counties, however Waukesha wasn’t certainly one of them.

CWD is a deadly prion illness that impacts cervids like deer, elk, and moose and is a rising menace to deer herds. No human instances have been reported, however well being officers warn in opposition to consuming meat from CWD-infected animals because of the threat of contracting an sickness just like bovine spongiform encephalopathy (“mad cow” illness), which can also be attributable to prions.
Nov 9 Wisconsin DATCP assertion


Excessive-path avian flu outbreaks strike poultry in Japan, South Korea, Europe

Japan and South Korea in the present day reported their first extremely pathogenic avian flu poultry outbreaks of the season, and Germany reported one other extremely pathogenic H5N1 outbreak in poultry, based on the newest official and media experiences.

Japan’s agriculture ministry stated the outbreak occurred at a layer farm in Akita prefecture that had reported an rising variety of hen deaths, based on a press release translated and posted by Avian Flu Diary (AFD), an infectious illness information weblog. The report did not say what subtype was concerned.

South Korea’s outbreak concerned H5N1 at a quail farm in North Chungcheong province, KBS Information reported. The nation had lately reported two H5N1 outbreaks in wild birds, in North Jeolla and South Chungcheong provinces.

In Europe, Germany reported one other H5N1 outbreak, this time at a farm that housed yard geese and layers in Mecklenburg-Vorpommern state, based on a notification from the World Group for Animal Well being (OIE). And Italy reported two H5N1 outbreaks in wild birds, each in Lombardy province. In each situations the virus was detected in hunter-harvested waterfowl.

In an up to date threat evaluation in the present day, the UK’s Division for Setting, Meals, and Agriculture (DEFRA) raised the chance of extremely pathogenic H5 virus unfold in wild birds from medium to excessive, based mostly on an elevated frequency of H5N1 detections in each wild birds and poultry since its final report in late October. For poultry, it put the chance at low to medium, based mostly on biosecurity situations.
Nov 10 AFD put up
Nov 10 KBS Information story
Nov 9 OIE report on H5N1 in Germany
Nov 9 OIE report on H5N1 in Italy
Nov 10 DEFRA replace

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